Type 1 Diabetes Mellitus ( T1dm ) - 1456 Words

INTRODUCTION Type 1 diabetes mellitus (T1DM) is the most common metabolic disorder in which both genetic and environmental factors are involved [1]. T1DM is considered a chronic immune-mediated disorder. It was hypothesized that whilst children have a genetic predisposition to T1DM, there is likely to be an environmental factor that triggers the development of T1DM. Possible triggers that have been suggested include viral infection, vaccines, low levels of vitamin D and cow’s milk, [2]. Oxidative stress is one of the important pathways that have been involved in the etiopathogenesis of T1D [3]. Complications of T1DM could be due to the cellular metabolism leading to hyperglycemia and excess production of reactive oxygen species (ROS).†¦show more content†¦Objectives This study aimed to evaluate the association of glutathione S-transferase mu 1 (GST M1) and glutathione S-transferase theta 1 (GST T1) polymorphisms with the development of T1DM and disease- related risk factors. PATIENTS AND METHODS The study included 64 diabetic children with T1DM with a mean age of 11.7 ± 3.6 years; 26 boys and 38 girls. They were enrolled from the attendants of pediatric genetic and endocrinology unit and pediatric outpatient clinic of Menoufia university Hospitals, Egypt. The study was conducted in the period from January 2015 to March 2016. Diagnosis of T1DM patients was based on the American Diabetes Association (ADA) criteria [9]. Patients were followed up , regularly checked and investigated accordingly for diabetic complications , their current treatment regimens. Cases suffering from 2ry diabetes , or having chronic-related diseases , like hypothyroidism or hyperthyroidism or hypoadrenalism were excluded. Forty-one apparently healthy children of matched age and sex served as a control group. Written informed consent was obtained from each child included in the study or their participant parents. Ethical clearance was obtained for the research project. The study protocol conforms to the ethical guidelines of the 1964 Declaration of Helsinki and its later amendments. Data about the duration of illness and onset of the disease in children with T1DM were taken. BodyShow MoreRelatedType 1 Diabetes Mellitus ( T1dm )2058 Words   |  9 PagesType 1 diabetes mellitus (T1DM) results from a defect in insulin secretion in the body. T1DM may happen at any age and it is one of the most common chronic diseases of childhood and adolescents (Misso, Egberts, Page, O’Connor, Shaw, 2010). Long-term complications of T1DM include retinopathy, nephropathy, neuropathy, and cardiovascular disease. There is no prevention or cure for T1DM, and the treatment is a life-long insulin replacement regimen. Proper and accurate glycemic control is critical toRead MoreApplication Of Type 1 Diabetes Mellitus3781 Words   |  16 PagesTable of Contents I. Introduction to Type 1 Diabetes Mellitus a. What it is b. Prevalence and demographics c. Treatment II. Cognitive Outcomes: Mood and Memory a. Memory i. Neural Basis of Memory ii. Cognitive Outcome of TIDM on Memory III. Structural Brain Changes: MRI Studies a. The Hippocampus i. Purpose and Function of the Hippocampus ii. Previous studies on T1DM and Hippocampal Volume iii. The Cognitive Effects of T1DM on Hippocampal Volume b. Other Brain Areas IV. Conclusion aRead MoreThe Dental Management Of Diabetes Essay1125 Words   |  5 PagesIntroduction Diabetes mellitus (DM) is not a single disease entity; rather, it is a group of metabolic diseases characterised by hyperglycaemia (elevated blood sugar level) affecting the metabolism of carbohydrates, proteins and fats, resulting from the inability of the body to secrete and/or use insulin (Al-Maskari, Al-Maskari, Al-Sudairy, 2011; American Diabetes Association, 2005; James W Little, Donald A Falace, Craig S Miller, Nelson L Rhodus, 2013a; World Health Organisation, 2016). PatientsRead MoreIncreasing Coping Skills in Parents of Children with Type 1 Diabetes1629 Words   |  7 PagesAccording to the U.S Department of Health and Human Services, there are 15,600 new cases of Type I Diabetes Mellitus (T1DM) each year (U.S Department of Health and Human Services, 2011). Boys and girls are at relatively equal risks for developing T1DM up until fourteen years old, with risks peaking around puberty. Following puberty, incidences tend to be higher in white males than women (Soltesz, Pat terson, Dahlquist, 2007). When looking globally by region at incidences, they tend to be higherRead MoreDiabetes Mellitus As A Group Of Metabolic Diseases Essay1472 Words   |  6 PagesIntroduction Diabetes mellitus is a group of metabolic diseases characterised by hyperglycaemia (elevated blood sugar level) affecting the metabolism of carbohydrates, proteins and fats, resulting from the inability of the body to secrete and/or use insulin (American Diabetes Association (ADA), 2005; World Health Organisation (WHO), 2016). Patients with type-1 Diabetes Mellitus (T1DM) requires insulin for survival as the cell-mediated destruction of the ÃŽ ²-cells of the pancreas eventually lead toRead MoreThe Health Problem Surrounding Type 1 Diabetes2334 Words   |  10 Pages This paper will discuss and critically analyze the health problem surrounding Type 1 Diabetes (T1D) among the population. The findings of this paper will be summarized about the epidemiological concepts, the natural progression, and the treatment that can be provided for this pandemic issue. Current statistics and resources will be implemented throughout this paper. In addition, the Best Practice Guidelines will be anal yzed and implemented in order to provide effective care for those who are undergoingRead MoreType 1 Diabetes On Children Essay1011 Words   |  5 Pages Type 1 Diabetes In Children Kathy Miron Beckfield Mrs. Rebecca Barner December 2, 2016 Type 1 Diabetes In Children Helen Keller once said, â€Å"All the world is full of suffering. It is also full of overcoming.† Throughout life each person will face obstacles, but will only be defined by how they overcome or fail. In today’s society health and wellness has become such a challenge. Many things in our environment, social status, financial position, and culture can affect what we eat and ourRead MoreDiabetes : An Autoimmune Disease927 Words   |  4 Pagesnot news to anyone that one of the most known disease in the world is diabetes mellitus, people with type two diabetes produces some insulin, but not enough to keep their blood sugar at a normal level, however the one that are affected by the type 1 diabetes or childhood-onset type 1 DM do not produce insulin at all. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. (ADA, 2015) . That circumstance puts them at greater risk for heart diseaseRead MoreDiabetes And How A Person With This Condition s Experience Has Affected Her Daily Life1401 Words   |  6 PagesIntroduction In my paper, I am going to focus on Type 2 Diabetes and how a person with this condition’s experience has affected her daily life. About the Disability Cause: Experts say diabetes is partly genetic and at least partly behavioral. Obesity and lack of exercise are key risk factors for the most common form. Many people think that diabetes results from eating too many sweets, but the truth is more complex. Type 2 diabetes -- also known as adult-onset diabetes -- is characterized by â€Å"insulin resistanceRead MoreEssay on The Increasing Prevelance of Type 2 Diabetes1011 Words   |  5 Pagesrecently, the common type of diabetes in children and teens was the type 1, little wonder it was called juvenile diabetes. Type 1 diabetes mellitus (T1DM) is one of the most common chronic, unremitting medical conditions that develop in childhood or adolescence. There is a bimodal age of onset, with the first peak at 4 to 6 years and the second peak in early adolescence. But now younger people are also getting type 2 diabetes. Type 2 diabetes used to be called adult-onset diabetes. But now it is becoming

The Relations between Science and Religion Essay - 1630 Words

The relations between science and religion. Humans are servant of God who descended to earth as its inhabitants. Humans are creatures of God are given the advantage of reasonable than other creatures. With that human minds can do more than any other creature. At the beginning of its creation, only human beings who do not know anything and therefore people need a hint for his life. Humans need a guideline in order to survive life in the world and in the hereafter. Guideline for humans is religion. Religion is a hint of life, encompasses all aspects of human beings, including science. So many recent scientific discoveries in modern times was already confirmed. With scientific evidence in accordance with the scriptures, it can be†¦show more content†¦So ilmuadalah knowledge that meet specific characteristics and terms are standardized into a science , the two terms are combined into one word. Can be formulated also that science is as common knowledge ilmiahdan merged into science directly. The application of science in the world modeern has produced many technologies that make peoples lives healthier, more comfortable, and more secure. While the science is also one way to seek the truth, which is the objective truth. Even so, science tends to be autonomous so therefore he is often seen as the only path to truth. As a result we often face a clash between science and religion in the field of theology. The problem is, science is actually just talking about the objective reality of nature and humans. When in fact the religion talk about a whole person, body and soul are, and the broadest nature, ie the real nature and the supernatural, as well as kenyataam entirely, namely nature and god of creation. So in fact there is the intersection between the two, yait on nature and human problems. There is no contradiction between the two. But in the course of history several centuries after reinaisans, scientific revolution, followed by the industrial revolution, our scientific knowledge about ourselves and our natural environment has changed dramatically. Unfortunately the new picture for a lot of people tend to negate the description given by the theology of worldShow MoreRelatedRelation Between Science and Religion Essay4079 Words   |  17 Pageson What is the Relation between Science and Religion William Lane Craig Examines several ways in which science and theology relate to each other. Back in 1896 the president of Cornell University Andrew Dickson White published a book entitled A History of the Warfare of Science with Theology in Christendom. Under White’s influence, the metaphor of â€Å"warfare† to describe the relations between science and the Christian faith became very widespread during the first half of the 20th century. The culturallyRead MoreEmile Durkheim s The Elementary Forms Of The Religious Life1608 Words   |  7 Pagesexamines religion through a social viewpoint, while Claude Là ©vi-Strauss’s The Savage Mind compares modern and â€Å"primitive† thought. Although their topics of interest differ, both works similarly rely on science to explain their anthropologic theories. Science serves as a useful reference point, since it embodies modern mode of thinking with high objectivity. Therefore, these writers can expand on their analysis of other ways to perceive the world by comparing and contrasting with science. The relati onsRead MoreMonotheistic religions, especially Judaism, Christianity, and Islam promote the belief in One God;1600 Words   |  7 PagesMonotheistic religions, especially Judaism, Christianity, and Islam promote the belief in One God; all that exists is because of God. Through prophets and scripture, God portrays moral goodness and truth. Essentially, these three religions believe that God speaks to us, unveils God’s Being, and seeks to guide us through life. In turn, humans should embody the moral goodness and excellence that is revealed to us by God. These religions are taught based upon both scripture and reason. When readingRead MoreThe Secularization of the Western World Essay1680 Words   |  7 Pagesmeanings over the past eighteen centuries. In today society, the world secular is used to describe a world thought to be in motion, the moving away from religious influence in everyday life. Thus, my definition of the term secularism is not denouncing religion to an anti-religious belief but rather viewing secularism as a point of view that reflects the change in society to seek answers and meet the needs of people without taking on religious perspective. â€Å"The shift towards secularism does not mean thatRead MoreI Appreciate Barbour s Praiseworthy And Toilsome Effort914 Words   |  4 PagesIII. Critique First of all, I appreciate Barbour’s praiseworthy and toilsome effort to put theology and science in a meaningful and fruitful dialogue, by seriously taking account of both continuities and discontinuities between scientific metaphors and religious metaphors. For Barbour, because both disciplines have continuities and discontinuities they can contribute to our more comprehensive understanding of the reality of our experiences in the world through their metaphorical relationshipRead MoreBecause Religion Is A Difficult Concept To Define, It Faces1709 Words   |  7 PagesBecause religion is a difficult concept to define, it faces several criticisms. To this day, it has never been possible to find a definition of religion that pleases the majority of the population. However, researchers in this area have never felt the need to have a definition to carry out their research. Religion is a somewhat different concept of economy, politics or history and the difficulty of defining it comes from the fact that these are not index terms but rather general concepts thatRead More what is theology Essay995 Words   |  4 Pages What is theology? What does it explain if anything? According to the encyclopedia, it is related to the Greek Religion. In Christianity, the systematic study of the nature of God and Gods relationship with humanity and with the world. Although other religions may be said to have theologies, this is a matter of controversy within, for instance, Judaism , which holds that God is unknowable. This article will therefore confine itself to Christian theology. The development of theology in ChristendomRead MoreThe Star by Arthur C. Clarke and the Juxtaposition of Science and Religion704 Words   |  3 Pages When dwelling into the explorations about science and religion, one can find it quite amusing. If science and religion are to continue to coexist it seems opposed to the conditions of modern thought to admit that this result can be brought about by the so-called water-tight compartment system which, even at the present time, is frequently extolled or considered possible.(Boutroux, 406) Two powerful forces that coexist yet each of them deny one another, but yet they define one another. TheRead MoreHow Do We Know and What We Know? Essay734 Words   |  3 Pagesdifferent situations. Vocabulary and speech pattern between friends or relatives may be informal and familiar whereas communication with someone of different generation, class or age group is likely to be specific to the particular relationship, place or moment. Knowledge is shaped by social institution and by the power groups and individuals to influence the generation and acceptance of knowledge such as legal system, and education system. Religion is a special case of authority over knowledgeRead MoreCan Religion and Science be Compatible?1326 Words   |  5 PagesCan Religion and Science be Compatible? Accepting the compatibility between science and religion is a tactic used by those who instinctively fear that a manifest conflict between the two areas would endanger the future of science. They are worried about the possibility that scientists would not receive any financial support or that science classes in schools might be replaced with hours of religion. A huge number of atheist scientists are aware of the negative role, that they have irrational ideas

One Day Acuvue free essay sample

Vistakon seeks to be the leader in providing soft, daily disposable, high-quality contact lenses to the part-time lens user by providing superior quality products through innovative manufacturing and RD combined with strong advertising presence and trade support. In 1987, Vistakon, an independent subsidiary of Johnson Johnson, introduced Acuvue, the first soft, disposable contact lens through marked innovations in production and marketing.The â€Å"stabilized soft molding† production technique, promising better quality through reducing imperfections, coupled with a dual pronged marketing campaign that â€Å"pulled† consumers to enquire about Acuvue through extensive advertising and promotions and â€Å"pushed† the product by educating Eye Care Professionals (ECPs) on the product’s superior features resulted in Vistakon dominating the soft disposable contact lens market (with a 18. 9% market share) by 1993. To continue building up on its success, Vistakon developed 1 Day Acuvue, the first daily disposable contact lens. However, marketing tests revealed multiple issues with existing product cannibalization (of current products with sales up to $250 million), pricing and positioning, targeted markets, and the optimal marketing campaign. We will write a custom essay sample on One Day Acuvue or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The firm needed to decide if more marketing tests are required to gain more perception into these issues or to embark immediately on a nationwide launch. Vistakon initially targeted 1 Day Acuvue to three market segments, contact lens dropouts (size: 15. 5 million, exhibit 2), patients with medical problems or active lifestyle consumers, and conventional daily wear users (size: 4. 6 million, exhibit 2).The western regional rollout indicates that 88% of all 1 Day Acuvue customers utilized contact lenses prior to purchase, a majority of whom used contact lenses in conjunction with spectacles. Exhibit 18 indicates that 1 Day Acuvue was also preferred by college graduates earning $81,000 or more primarily between the ages of 18-45 who frequently travel on business. This data insinuates that 1 Day Acuvue should be targeted towards two specific markets: high income business travelers and athletes and medical patients. Both segments share common characteristics of being less price-sensitive and being current users of disposable soft lenses.While the dropout market is potentially lucrative, it will be hard for the ECP or Vistakon to convince this market that 1-Day Acuvue possesses benefits far beyond their prior contact lens, specifically for the 65% who discontinued because of cost, discomfort, ease of use, need for bifocals, and loss/tear in lens. Exhibit 10 indicates that the gross margins fell from 88% to 40% with the advent of disposables. ECPs currently make $464. 00/patient/2 years from current disposables, whereas the initial costing policy of 1 Day Acuvue would reduce that contribution to $194. 40 (calculations in appendix 1). This is probably the primary reason why ECPs did not push 1 Day Acuvue as strongly as Vistakon expected during marketing tests (with only 20% of ECPs emphasizing the cost/day marketing strategy and 33% of ECPs stating that Acuvue was the most expensive lens). Vistakon somewhat corrected this issue with its new pricing policy in the western regional launch, with the contribution to ECPs who availed the volume discount for orders more than 4 30 packs increasing to $408/patient/2 years (calculations in appendix 1). This also helped reduce ECPs emphasizing Acuvue as most expensive (6%).

Analysis Of The Holocaust Essays (1615 words) - The Holocaust

Analysis of the Holocaust Of all the examples of injustice against humanity in history, the Jewish Holocaust has to be one of the most prominent. In the period of 1933 to 1945, the Nazis waged a vicious war against Jews and other "lesser races". This war came to a head with the "Final Solution" in 1938. One of the end results of the Final Solution was the horrible concentration and death camps of Germany, Poland, and other parts of Nazi-controlled Europe. In the aftermath of the Holocaust, people around the world were shocked by final tallies of human losses, and the people responsible were punished for their inhuman acts. The Holocaust was a dark time in the history of the 20th century. One can trace the beginnings of the Holocaust as far back as 1933, when the Nazi party of Germany, lead by Adolf Hitler, came to power. Hitler's anti-Jew campaign began soon afterward, with the "Nuremberg Laws", which defined the meaning of being Jewish based on ancestry. These laws also forced segregation between Jews and the rest of the public. It was only a dim indication of what the future held for European Jews. Anti-Jewish aggression continued for years after the passing of the Nuremberg Laws. One of these was the "Aryanization" of Jewish property and business. Jews were progressively forced out of the economy of Germany, their assets turned over to the government and the German public. Other forms of degradation were pogroms, or organized demonstrations against Jews. The first, and most infamous, of these pogroms was Krystallnacht, or "The night of broken glass". This pogrom was prompted by the assassination of Ernst von Rath, a German diplomat, by Herschel Grymozpan in Paris on November 7th, 1938. Two days later, an act of retaliation was organized by Joseph Gobbels to attack Jews in Germany. On the nights of November 9th and 10th, over 7,000 Jewish businesses were destroyed, 175 synagogues demolished, nearly 100 Jews had been killed, and thousands more had been injured, all for the assassination of one official by a Jew ("Holocaust, the." Microsoft Encarta 96). In many ways, this was the first major act of violence to Jews made by the Nazis. Their intentions were now clear. The Nazi's plans for the Jews of Europe were outlined in the "Final Solution to the Jewish question" in 1938. In a meeting of some of Hitler's top officials, the idea of the complete annihilation of Jews in Europe was hatched. By the time the meeting was over, the Final Solution had been created. The plans included in the Final Solution included the deportation, exploitation, and eventual extermination of European Jews. In September 1939, Germany invaded western Poland. Most, if not all Jews in German-occupied lands were rounded up and taken to ghettos or concentration camps. The ghettos were located inside cities, and were a sort of city/prison to segregate Jews from the rest of the public. Conditions in the ghettos included overcrowding, lack of food, and lack of sanitation, as well as brutality by Nazi guards. Quality of life in a ghetto was probably not much above that in a concentration camp. In June 1941, Germany continued it's invasion of Europe by attacking and capturing some of the western U.S.S.R. By this time, most of the Jews in Europe now lived in lands controlled by Nazi Germany. The SS deployed 3000 death squads, or "Einstagruppen", to dispatch Jews in large numbers ("Holocaust, the." Microsoft Encarta 1996). In September 1941, all Jews were forced to wear yellow Stars of David on their arms or coats. A Jew could be killed with little repercussions for not displaying the Star of David in public. Some of the first Jewish resistance to the Final Solution came in 1943, when the process of deportation to concentration and death camps was in full swing. The Warsaw ghetto in Poland, once numbering over 365,000, had been reduced to only 65,000 by the continuing removal of Jews to camps in other lands ("Holocaust, the." Microsoft Encarta 1996). When the Nazis came to round up the remaining inhabitants of the ghetto, they were met with resistance from the small force of armed Jews. The revolt lasted for almost three weeks

Free Essays on Andrew Lloyd Webber

Andrew Lloyd Webber was born on March 22, 1948 to William and Jean Lloyd Webber. In 1951 his younger brother Julian was born. Even at a young age, Andrew loved to make his own music. Andrew also had a great interest in inspecting ancient monuments around England. It and history were what many thought he would choose to do for a career. However, his Aunt Vi introduced him to the theatre, and under her advice started writing music of his own. In 1956, Andrew went to Westminster and started composing music for the school's plays. In 1962, Andrew won a Challenge Scholarship that reduced his tuition at Westminster. Andrew won another scholarship in 1964 to transfer to Oxford. Time Rice and Andrew met in 1965 and consequently, Andrew dropped out of Oxford to pursue music with Tim. The first musical, The Likes of Us, was a failure, but soon afterwards Joseph was created. The first showing was at Colet Court in 1968. Jesus Christ Superstar came next. In 1971, Andrew married Sarah Jane Hugill . Andrew and Alan Ayckbourn, in 1975, started work on a new musical, Jeeves. Jeeves was not a success and Andrew went back to Tim. Together they wrote Evita in late 1975. The next musical, Cats, paired Andrew with the deceased poet T.S. Eliot and producer, Cameron Mackintosh. It was an incredible hit and beat A Chorus Line for longest running musical and highest grossing musical. Cats made Andrew rich and famous and ready to start a musical about trains. Starlight Express was created in 1984, the most expensive musical created up to that point. The same year, Andrew divorced Sarah Hugill and married Sarah Brightman. Andrew's next work was Requiem. It isn't a musical, but serious music for a Mass. Sarah Brightman sang the female soprano part. Andrew's next work, Phantom of the Opera also included Sarah. One of Andrew's most famous works, Phantom was created in 1986. Aspects of Love, Andrew's next venture, opened in 1989. Its intimate setting and songs were cr... Free Essays on Andrew Lloyd Webber Free Essays on Andrew Lloyd Webber Andrew Lloyd Webber was born on March 22, 1948 to William and Jean Lloyd Webber. In 1951 his younger brother Julian was born. Even at a young age, Andrew loved to make his own music. Andrew also had a great interest in inspecting ancient monuments around England. It and history were what many thought he would choose to do for a career. However, his Aunt Vi introduced him to the theatre, and under her advice started writing music of his own. In 1956, Andrew went to Westminster and started composing music for the school's plays. In 1962, Andrew won a Challenge Scholarship that reduced his tuition at Westminster. Andrew won another scholarship in 1964 to transfer to Oxford. Time Rice and Andrew met in 1965 and consequently, Andrew dropped out of Oxford to pursue music with Tim. The first musical, The Likes of Us, was a failure, but soon afterwards Joseph was created. The first showing was at Colet Court in 1968. Jesus Christ Superstar came next. In 1971, Andrew married Sarah Jane Hugill . Andrew and Alan Ayckbourn, in 1975, started work on a new musical, Jeeves. Jeeves was not a success and Andrew went back to Tim. Together they wrote Evita in late 1975. The next musical, Cats, paired Andrew with the deceased poet T.S. Eliot and producer, Cameron Mackintosh. It was an incredible hit and beat A Chorus Line for longest running musical and highest grossing musical. Cats made Andrew rich and famous and ready to start a musical about trains. Starlight Express was created in 1984, the most expensive musical created up to that point. The same year, Andrew divorced Sarah Hugill and married Sarah Brightman. Andrew's next work was Requiem. It isn't a musical, but serious music for a Mass. Sarah Brightman sang the female soprano part. Andrew's next work, Phantom of the Opera also included Sarah. One of Andrew's most famous works, Phantom was created in 1986. Aspects of Love, Andrew's next venture, opened in 1989. Its intimate setting and songs were cr...

Business Analysis Essay Example | Topics and Well Written Essays - 1000 words

Business Analysis - Essay Example The cash flow for a particular period reflects the flow of cash in future for that period. But due to a loss in the time value of money, the present value of the cash flow is actually less than the actual value. To have a realistic view of the cash flows the actual values need to be converted into what are called as the Present Values. The factor by which the actual value is multiplied to calculate the present value is called the Discount Factor. Discount factor lies between 0 and 1. It is determined by the rate of return on capital during a given period and can be calculated using compounding (Johnson, Derek). Using the net present value approach, it can be found out that the net cash flows are positive in all quarters and the initial investment is also recovered within a quarter. The Net present value is hence positive and comes out as  £5,030,687. The NPV (Net Present value) calculations can be done using an excel spread sheet. An extract of the same is shown in Figure 2.1. Thus, it can be concluded from this that, the boutique must go with the development plan. There are several key factors that can affect the cash flows. One of them is the Build-up factor. If the build-up factor becomes negative i.e. there is a decrease in income in the following quarters due to some reason, the NPV decreases. The NPV turns negative at -57% build-up factor for each quarter as shown in Figure 3.1. This is where the decision gets reversed. This could happen in case of adverse external circumstances. The second factor which can affect cash flow is Cost of Sales. If due to an increase in raw material costs or due to some other factors, Cost of Sales rise as much as 89% of the sales, the NPV becomes negative and the decision has to be reversed. This is shown in Figure 3.2. Thirdly, the increase in rent can have an impact on net cash flows especially in wake of continuously rising real estate prices. If the rent increases to  £1427 per sq. m.,

Ready to Die Essay Example | Topics and Well Written Essays - 500 words

Ready to Die - Essay Example I believe it is crucial for the living to use part of their health time and energy in preparing for death. There are various ways to prepare for death as exemplified by Nicholson and Freeman in the movie ‘Bucket List’ (Knox, 2007). One of the ways to prepare for oneself death is thinking about it. We should have brief moments possibly in a day and reflect on what can happen if death occurs. I do not mean we dwell on death but to appreciate the reality about it and live fully while knowing it will happen. People can embrace life after realizing they have limited time in the world. Nicholson and Freeman opted to enjoy life after accepting that the death is a reality. They believed that it was awaiting them, and as a result, stopped staying in the hospital beds with agony. I also think we should make a ‘bucket list’ as one way of preparing for our death. ‘Bucket list’ involves having a list of things we want to do, life experiences we want to achieve, and places we want to go. Nicholson and Freeman realized this very late; they had a long ‘bucket list’ despite having much wealth and less time (Knox, 2007). As evidenced by Nicholas and Freeman, we do not carry with us material possession and hence we should utilize the resources we have in meeting our objectives. We should not allow death to scare and bar us from enjoying life, instead, we are supposed to use it as a wake-up call to maximize our limited time in the world. In addition, people should write their last statement and will instead of fearing to think about death that may result from our cultural beliefs. The last statement and will are used to designate what will happen to our properties and guardianship of our children. Many properties get lost when one dies without leaving a documented will. Lack of a documented will may also lead to occurrence of conflicts among the left relatives. For